We believe in a lifespan and holistic approach to mental health that traverses the care and services that are currently provided to both mothers and children. We study risk and resilience processes that influence psychopathology during pregnancy, through delivery and the early postpartum period, and into the first few years of life. In collaboration with colleagues in Penn Medicine and the Children’s Hospital of Philadelphia, we take a multi-method approach to characterize the experiences of both mother and child, bringing together obstetrics, pediatrics, psychiatry, and psychology. Through this work, we hope to inform more effective intervention and prevention efforts to identify families who need support during pregnancy or postpartum period, thus promoting resilience, confident parenting, and positive child development.